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KMID : 0359920150340020117
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Korean Journal of Nephrology
2015 Volume.34 No. 2 p.117 ~ p.119
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Fibrillary glomerulonephritis combined with chronic infl ammatory demyelinating polyneuropathy
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Sung Woo-Kyung
Jeong Jin-Uk
Bang Ki-Tae
Shin Jong-Ho
Yoo Ji-Hyung
Kim Nak-Min
Park Jun-Hyung
Kim Joo-Heon
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Abstract
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A 58-yr-old man presented with leg edema and subacute weakness of his bilateral lower extremities. Urinary and serum immunoelectrophoresis revealed the presence of lambda-type Bence Jones proteins. He was ultimately diagnosed with
monoclonal gammopathy of undetermined significance (MGUS). A renal biopsy specimen showed fibrillary glomerulonephritis (FGN), which was randomly arranged as 12?20 m nonbranching fibrils in the basement membranes. Immunofluorescence studies were negative for immunoglobulin (Ig)G, IgM, IgA, C3, and kappa light chains in the capillary walls and mesangial areas. A Congo red stain for amyloid was negative. Electromyography and nerve conduction velocity examinations results were compatible with the presence of demyelinating polyneuropathy. This case showed a rare combination of FGN, without Ig deposition, and MGUS combined with chronic inflammatory demyelinating polyneuropathy (CIDP).
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KEYWORD
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Fibrillary glomerulonephritis, Monoclonal gammopathy, Polyneuropathy
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